- Clb5 Clb6 Mutants
- clb5∆ clb6∆
- TAB6-1 clb5∆ clb6∆
- cdc20∆ clb5∆
- cdc20∆ pds1∆ clb5∆
- CLB2-db∆ clb5∆
- CLB2-db∆ clb5∆ in galactose
- cln1∆ cln2∆ clb5∆ clb6∆
- CLB5-db∆
- CLB5-db∆ sic1∆
- CLB5-db∆ pds1∆
- CLB5-db∆ pds1∆ cdc20∆
- GAL-CLB5
- GAL-CLB5 cdh1∆
- GAL-CLB5 sic1∆
- GAL-CLB5-db∆
- cln1∆ cln2∆ cln3∆ multi-copy CLB5
- cln1∆ cln2∆ cln3∆ GAL-CLB5
GAL-CLB5
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksb5'=0.012, MDT=150.
Length of G1 phase: 101.9 min.
Mass at division: 1.82
Experiments:
Schwob, E. and Nasmyth, K.(1993). CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae. Genes Dev. 7:1160-1175.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig. 6C, GAL-CLB5 did not cause advancement of CLN1 transcription, nor premature DNA replication, as compared to wild type.
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Because sic1∆ cells (which still has functional Cdc6 in G1) show advance in DNA synthesis by 30 min, it indicates that Cdc6 is not as strong an inhibitor to Clb5.